Octreotide may improve pharyngocutaneous fistula healing through downregulation of cystatins: A pilot study.

ABSTRACT:

Background

Pharyngocutaneous fistula (PCF) and salivary leaks are well known complications of head and neck surgery. The medical management of PCF has included the use of octreotide without a well-defined understanding of its therapeutic mechanism. We hypothesized that octreotide induces alterations in the saliva proteome and that these alterations may provide insight into the mechanism of action underlying improved PCF healing. We undertook an exploratory pilot study in healthy controls that involved collecting saliva before and after a subcutaneous injection of octreotide and performing proteomic analysis to determine the effects of octreotide.

Methods

Four healthy adult participants provided saliva samples before and after subcutaneous injection of octreotide. A mass-spec

SUBMITTER: Cohen J 

PROVIDER: S-EPMC9948565 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature