Reduced D₂ /D₃ Receptor Binding and Glucose Metabolism in a Macaque Model of Huntington's Disease.

ABSTRACT:

Background

Dopamine system dysfunction and altered glucose metabolism are implicated in Huntington's disease (HD), a neurological disease caused by mutant huntingtin (mHTT) expression.

Objective

The aim was to characterize alterations in cerebral dopamine D₂ /D₃ receptor density and glucose utilization in a newly developed AAV-mediated NHP model of HD that expresses mHTT throughout numerous brain regions.

Methods

Positron emission tomography (PET) imaging was performed using [¹⁸ F]fallypride to quantify D₂ /D₃ receptor density and 2-[¹⁸ F]fluoro-2-deoxy-d-glucose ([¹⁸ F]FDG) to measure cerebral glucose utilization in these HD macaques.

Results

Compared to controls, HD macaques showed s

SUBMITTER: Weiss AR 

PROVIDER: S-EPMC9948637 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature