Ontology highlight
ABSTRACT: Significance
A proof-of-principle study in animal models shows that a novel local drug delivery approach can prevent tumor recurrence as well as drug-related adverse events following surgical resection of soft-tissue sarcomas.
SUBMITTER: Bressler EM
PROVIDER: S-EPMC9948765 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Bressler Eric M EM Chu Ngoc-Quynh NQ Sabatelle Robert C RC Mahvi David A DA Korunes-Miller Jenny T JT Nagashima Fumiaki F Ichinose Fumito F Liu Rong R Grinstaff Mark W MW Colson Yolonda L YL Raut Chandrajit P CP
Cancer research 20221201 23
Surgery is the only potentially curative treatment for localized soft-tissue sarcomas. However, for sarcomas arising in the retroperitoneum, locoregional recurrence rates are 35% to 59% despite resection. Doxorubicin (DOX) is the standard first-line systemic chemotherapy for advanced soft-tissue sarcoma, yet its intravenous administration yields limited clinical efficacy and results in dose-limiting cardiotoxicity. We report the fabrication and optimization of a novel electrospun poly(caprolacto ...[more]