The Embryonic Origin of Primordial Germ Cells in the Tardigrade Hypsibius exemplaris.

ABSTRACT: Primordial germ cells (PGCs) give rise to gametes â€" cells necessary for the propagation and fertility of diverse organisms. Current understanding of PGC development is limited to the small number of organisms whose PGCs have been identified and studied. Expanding the field to include little-studied taxa and emerging model organisms is important to understand the full breadth of the evolution of PGC development. In the phylum Tardigrada, no early cell lineages have been identified to date using molecular markers. This includes the PGC lineage. Here, we describe PGC development in the model tardigrade Hypsibius exemplaris . The four earliest-internalizing cells (EICs) exhibit PGC-like behavior and nuclear morphology. The location of the EICs is enriched for mRNAs of conserved PGC ma

SUBMITTER: Heikes KL 

PROVIDER: S-EPMC9948961 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature