Ketamine-based Versus Fentanyl-based Regimen for Rapid-sequence Endotracheal Intubation in Patients with Septic Shock: A Randomised Controlled Trial.

ABSTRACT:

Objective

The aim of this work is to compared ketamine-based versus fentanyl-based regimens for endotracheal intubation in patients with septic shock undergoing emergency surgery.

Design

This was a randomised double-blinded controlled trial.

Participants

Patients with septic shock on norepinephrine infusion scheduled for emergency surgery.

Setting and interventions

At induction of anaesthesia, patients were allocated into ketamine group (n=23) in which the participants received ketamine 1 mg/kg, and fentanyl group (n=19) in which the participants received fentanyl 2.5 mcg/ kg. Both groups received midazolam (0.05 mg/kg) and succinyl choline (1 mg/kg).

Measurement

The primary outcome was mean arterial blood pressure. The secondary outcomes included: heart

SUBMITTER: Ali H 

PROVIDER: S-EPMC9949025 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature