Alteration of functional connectivity in the cortex and major brain networks of non-human primates following focused ultrasound exposure.

ABSTRACT: Focused ultrasound (FUS) is a non-invasive neuromodulation technology that is being investigated for potential treatment of neurological and psychiatric disorders. Focused ultrasound combined with microbubbles can temporarily open the intact blood-brain barrier (BBB) of animals and humans, and facilitate drug delivery. FUS exposure, either with or without microbubbles, has been demonstrated to alter the behavior of non-human primates, and previous work has demonstrated transient and long-term effects of FUS neuromodulation on functional connectivity using resting state functional MRI. However, it is unknown whether opening the BBB affects functional connectivity differently than FUS alone. Thus we applied FUS alone (neuromodulation) and FUS with microbubbles (BBB opening) in the dorsal str

SUBMITTER: Liu D 

PROVIDER: S-EPMC9949083 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature