Somatodendritic orientation determines tDCS-induced neuromodulation of Purkinje cell activity in awake mice.

ABSTRACT: Transcranial direct-current stimulation (tDCS) of the cerebellum is a promising non-invasive neuromodulatory technique being proposed for the treatment of neurological and neuropsychiatric disorders. However, there is a lack of knowledge about how externally applied currents affect neuronal spiking activity in cerebellar circuits in vivo. In this study, we observe that tDCS induces a heterogeneous polarity-dependent modulation of the firing rate of Purkinje cells (PC) and non-PC in the mouse cerebellar cortex. Using a combination of juxtacellular labeling and high-density Neuropixels recordings, we demonstrate that the apparently heterogeneous effects of tDCS on PC activity can be explained by taking into account the somatodendritic orientation relative to the electric field. Our fi

SUBMITTER: Sanchez-Leon CA 

PROVIDER: S-EPMC9949160 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature