Diffuse myocardial fibrosis associates with incident ventricular arrhythmia in implantable cardioverter defibrillator recipients.

ABSTRACT:

Background

Diffuse myocardial fibrosis (DMF) quantified by extracellular volume (ECV) may represent a vulnerable phenotype and associate with life threatening ventricular arrhythmias more than focal myocardial fibrosis. This principle remains important because 1) risk stratification for implantable cardioverter defibrillators (ICD) remains challenging, and 2) DMF may respond to current or emerging medical therapies (reversible substrate).

Objectives

To evaluate the association between quantified by ECV in myocardium without focal fibrosis by late gadolinium enhancement (LGE) with time from ICD implantation to 1) appropriate shock, or 2) shock or anti-tachycardia pacing.

Methods

Among patients referred for cardiovascular magnetic resonance (CMR) without congenital dise

SUBMITTER: Olausson E 

PROVIDER: S-EPMC9949189 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature