Ontology highlight
ABSTRACT:
SUBMITTER: Aure MH
PROVIDER: S-EPMC9949235 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Aure Marit H MH Symonds Jennifer M JM Villapudua Carlos U CU Dodge Joshua T JT Werner Sabine S Knosp Wendy M WM Hoffman Matthew P MP
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Exocrine secretory acinar cells in salivary glands (SG) are critical for oral health and loss of functional acinar cells is a major clinical challenge. Fibroblast growth factor receptors (FGFR) are essential for early development of multiple organs, including SG. However, the role of FGFR signaling in specific epithelial SG populations later in development and during acinar differentiation are unknown. Here, we predicted FGFR dependence in specific populations using scRNAseq data and conditional ...[more]