Prescription stimulant use during long-term opioid therapy and risk for opioid use disorder.

ABSTRACT:

Background

Concurrent therapeutic prescribing of prescription stimulants with opioid analgesics is increasing in the United States. Stimulant medication use is associated with increased risk for long-term opioid therapy (LTOT), and LTOT is associated with increased risk for opioid use disorder (OUD).

Aims

To determine if stimulant prescriptions among those with LTOT (≥90 days) are associated with greater risk for opioid use disorder (OUD).

Methods

This retrospective cohort study from 2010 to 2018 used a United States, nationally distributed Optum© analytics Integrated Claims-Clinical dataset. Patients ≥18 years of age, and free of prevalent OUD in the two years prior to index were eligible. All patients had a new ≥90-day opioid prescription. The index date was day 91.

SUBMITTER: Scherrer JF 

PROVIDER: S-EPMC9949323 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature