Potential therapeutic targets for sarcopenia identified by Mendelian randomisation

ABSTRACT: Abstract

Background

Identifying sarcopenia’s causally associated plasma proteins would provide potential therapeutic targets.

Methods

We screened out sarcopenia-related proteins with genome-wide association studies (GWAS) summary data and cis-protein loci genetic instruments. Summary data of sarcopenia were obtained from a GWAS of 256,523 Europeans aged 60 years and over. The causal effects of the proteins were investigated by cis-Mendelian Randomisation (MR) and multiverse sensitivity analysis. We also explored the robust proteins’ causal associations with appendicular lean mass (ALM) and surveyed their druggability and clinical development activities.

Results

In sum, 60 proteins from plasma proteome analysis studies and 12 from other studies were enrolled for M

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PROVIDER: S-EPMC9949583 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature