Mediators of Racial Disparities in Heart Dose Among Whole Breast Radiotherapy Patients.

ABSTRACT:

Background

Racial disparities in survival of patients with cancer motivate research to quantify treatment disparities and evaluate multilevel determinants. Previous research has not evaluated cardiac radiation dose in large cohorts of breast cancer patients by race nor examined potential causes or implications of dose disparities.

Methods

We used a statewide consortium database to consecutively sample 8750 women who received whole breast radiotherapy between 2012 and 2018. We generated laterality- and fractionation-specific models of mean heart dose. We generated patient- and facility-level models to estimate race-specific cardiac doses. We incorporated our data into models to estimate disparities in ischemic cardiac event development and death. All statistical tests were 2-

SUBMITTER: Chapman CH 

PROVIDER: S-EPMC9949587 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature