Elevated energy costs of biomass production in mitochondrial respiration-deficient Saccharomyces cerevisia.

ABSTRACT: Microbial growth requires energy for maintaining the existing cells and producing components for the new ones. Microbes therefore invest a considerable amount of their resources into proteins needed for energy harvesting. Growth in different environments is associated with different energy demands for growth of yeast Saccharomyces cerevisiae, although the cross-condition differences remain poorly characterized. Furthermore, a direct comparison of the energy costs for the biosynthesis of the new biomass across conditions is not feasible experimentally; computational models, on the contrary, allow comparing the optimal metabolic strategies and quantify the respective costs of energy and nutrients. Thus in this study, we used a resource allocation model of S. cerevisiae to compare the optimal

SUBMITTER: Grigaitis P 

PROVIDER: S-EPMC9949590 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature