Strategies to investigate and mitigate collider bias in genetic and Mendelian randomisation studies of disease progression.

ABSTRACT: Genetic studies of disease progression can be used to identify factors that may influence survival or prognosis, which may differ from factors that influence on disease susceptibility. Studies of disease progression feed directly into therapeutics for disease, whereas studies of incidence inform prevention strategies. However, studies of disease progression are known to be affected by collider (also known as "index event") bias since the disease progression phenotype can only be observed for individuals who have the disease. This applies equally to observational and genetic studies, including genome-wide association studies and Mendelian randomisation (MR) analyses. In this paper, our aim is to review several statistical methods that can be used to detect and adjust for index event bias in

SUBMITTER: Mitchell RE 

PROVIDER: S-EPMC9949638 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature