Novel Bruton’s tyrosine kinase inhibitor TAS5315 suppresses the progression of inflammation and joint destruction in rodent collagen-induced arthritis

ABSTRACT: Rheumatoid arthritis is an inflammatory autoimmune disease, characterized by autoantibody production, synovial inflammation, and joint destruction. Its pathogenesis is due to environmental factors and genetic backgrounds. Bruton’s tyrosine kinase is a cytoplasmic non-receptor tyrosine kinase, expressed in most hematopoietic cell lineages, except T cells and plasma cells, and regulates various immune-related signaling pathways, thereby playing a crucial role in pathogenesis. Thus, inhibiting Bruton’s tyrosine kinase may prove beneficial in treating autoimmune diseases. In the present study, we characterized Bruton’s tyrosine kinase inhibitor, TAS5315, in vitro and evaluated its therapeutic effects in experimental arthritis models. TAS5315 markedly inhibited Bruton’s tyrosine kinase enzyme a

SUBMITTER: Akasaka D 

PROVIDER: S-EPMC9949657 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature