Nanosystems for oxidative stress regulation in the anti-inflammatory therapy of acute kidney injury.

ABSTRACT: Acute kidney injury (AKI) is a clinical syndrome that results from a rapid decline in renal structure or renal functional impairment with the main pathological feature of sublethal and lethal damage to renal tubular cells. However, many potential therapeutic agents cannot achieve the desired therapeutic effect because of their poor pharmacokinetics and short retention time in the kidneys. With the recent emergence and progress of nanotechnology, nanodrugs with unique physicochemical properties could prolong circulation time, enhance efficient targeted delivery, and elevate the accumulation of therapeutics that can cross the glomerular filtration barrier and indicate comprehensive application prospects in the prevention and treatment of AKI. In this review, various types of nanosystems (suc

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9949729 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature