Mortality and Sequential Organ Failure Assessment Score in Patients With Suspected Sepsis: The Impact of Acute and Preexisting Organ Failures and Infection Likelihood.

ABSTRACT: The Sequential Organ Failure Assessment (SOFA) was chosen in the definition of sepsis due to superior validity in predicting mortality. However, few studies have assessed the contributions of acute versus chronic organ failures to SOFA for mortality prediction.

Objectives

The main objective in this study was to assess the relative importance of chronic and acute organ failures in mortality prediction in patients with suspected sepsis at hospital admission. We also evaluated how the presence of infection influenced the ability of SOFA to predict 30-day mortality.

Design setting and participants

Single-center prospective cohort study including 1,313 adult patients with suspected sepsis in rapid response teams in the emergency department.

Main outcomes and measures

The ma

SUBMITTER: Christensen EE 

PROVIDER: S-EPMC9949839 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature