Characteristics of immunological events in Epstein-Barr virus infection in children with infectious mononucleosis.

ABSTRACT:

Backgrounds & aims

Epstein-Barr virus (EBV) infection occurs commonly in children and may cause acute infectious mononucleosis (AIM) and various malignant diseases. Host immune responses are key players in the resistance to EBV infection. We here assessed the immunological events and laboratory indicators of EBV infection, as well as determined the clinical usefulness of evaluating the severity and efficacy of antiviral therapy in AIM patients.

Methods

We enrolled 88 children with EBV infection. The immune environment was defined by immunological events such as frequencies of lymphocyte subsets, phenotypes of T cells, and their ability to secrete cytokines, and so on. This environment was analyzed in EBV-infected children with different viral loads and in children in differe

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9949895 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature