Identify Key Genes Correlated to Ischemia-Reperfusion Injury in Aging Livers.

ABSTRACT:

Background

With the intensification of population aging, the proportion of aging livers in the donor pool is increasing rapidly. Compared with young livers, aging livers are more susceptible to ischemia-reperfusion injury (IRI) during liver transplantation, which greatly affects the utilization rate of aging livers. The potential risk factors associated with IRI in aging livers have not been fully elucidated.

Methods

In this work, five human liver tissue expression profiling datasets (GSE61260, GSE107037, GSE89632, GSE133815, and GSE151648) and a total of 28 young and aging liver tissues of human (N = 20) and mouse (N = 8) were used to screen and verify the potential risk factors associated with aging livers being more prone to IRI. DrugBank Online was used to

SUBMITTER: Yan X 

PROVIDER: S-EPMC9949953 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature