Efficacy and safety of racemic ketamine and esketamine for depression: a systematic review and meta-analysis.

ABSTRACT:

Background

Racemic ketamine and esketamine have demonstrated rapid antidepressant effects. We aimed to review the efficacy and safety of racemic and esketamine for depression.

Research design and methods

We conducted a PRISMA-guided review for relevant randomized controlled trials of racemic or esketamine for unipolar or bipolar major depression from database inception through 2021. We conducted random-effects meta-analyses using pooled rate ratios (RRs) and Cohen's standardized mean differences (d) with their 95% confidence intervals (CI).

Results

We found 36 studies (2903 participants, 57% female, 45.1 +/- 7.0 years). Nine trials used esketamine, while the rest used racemic ketamine. The overall study quality was high. Treatment with any form of ketamine was associa

SUBMITTER: Bahji A 

PROVIDER: S-EPMC9949988 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature