Mechanisms of Peripheral and Central Sensitization in Osteoarthritis Pain.

ABSTRACT: Pain, the primary symptom of osteoarthritis (OA), reduces both the quality and quantity of life for patients. The pathophysiology of OA pain is complex and often difficult to explain solely by radiological structural changes. One reason for this discrepancy is pain sensitization (peripheral sensitization [PS] and central sensitization [CS]) in OA. Thus, an understanding of pain sensitization is important when considering treatment strategies and development for OA pain. In recent years, pro-inflammatory cytokines, nerve growth factors (NGFs), and serotonin have been identified as causative agents that induce peripheral and central sensitization and are becoming therapeutic targets for OA pain. However, the characteristics of the clinical manifestations of pain sensitization elicited by the

SUBMITTER: Ohashi Y 

PROVIDER: S-EPMC9949992 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature