TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.

ABSTRACT: Innate immunity represents one of the main host responses to viral infection.^1-3 STING (Stimulator of interferon genes), a crucial immune adapter functioning in host cells, mediates cGAS (Cyclic GMP-AMP Synthase) sensing of exogenous and endogenous DNA fragments and generates innate immune responses.⁴ Whether STING activation was involved in infection and replication of enterovirus remains largely unknown. In the present study, we discovered that human enterovirus A71 (EV-A71) infection triggered STING activation in a cGAS dependent manner. EV-A71 infection caused mitochondrial damage and the discharge of mitochondrial DNA into the cytosol of infected cells. However, during EV-A71 infection, cGAS-STING activation was attenuated. EV-A71 proteins were screened and the v

SUBMITTER: Zheng W 

PROVIDER: S-EPMC9950063 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature