TNF-α contributes to sarcopenia through caspase-8/caspase-3/GSDME-mediated pyroptosis.

ABSTRACT: Sarcopenia has become a leading cause of disability and mortality in the elderly. It has been reported that programmed cell death (PCD) is associated with the development of sarcopenia that is characterized by reduction of muscle fiber size and number. TNF-α is also validated to play a prominent role in sarcopenia through its complex signaling pathways including cell death signaling. However, it is still unclear whether TNF-α contributes to sarcopenia by mediating pyroptosis, one type of PCD. Here, we first established naturally aged mice with sarcopenia model and confirmed an inflammatory state represented by TNF-α in aged mice. Evidence of GSDME-mediated pyroptosis and activation of apoptotic caspase-8/-3 were also found in skeletal muscle cells of aged mice with sarcopenia. We demonstra

SUBMITTER: Wu J 

PROVIDER: S-EPMC9950087 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature