Genome-wide copy number variant screening of Saudi schizophrenia patients reveals larger deletions in cases versus controls.

ABSTRACT:

Introduction

Genome-wide association studies have discovered common polymorphisms in regions associated with schizophrenia. No genome-wide analyses have been performed in Saudi schizophrenia subjects.

Methods

Genome-wide genotyping data from 136 Saudi schizophrenia cases and 97 Saudi controls in addition to 4,625 American were examined for copy number variants (CNVs). A hidden Markov model approach was used to call CNVs.

Results

CNVs in schizophrenia cases were twice as large on average than CNVs in controls (p = 0.04). The analyses focused on extremely large >250 kilobases CNVs or homozygous deletions of any size. One extremely large deletion was noted in a single case (16.5 megabases on chromosome 10). Two cases had an 814 kb duplication of chromosome 7 spann

SUBMITTER: Abumadini MS 

PROVIDER: S-EPMC9950097 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature