Clcf1/Crlf1a-mediated signaling is neuroprotective and required for Muller glia proliferation in the light-damaged zebrafish retina

ABSTRACT: Zebrafish possess the innate ability to fully regenerate any neurons lost following a retinal injury. This response is mediated by Müller glia that reprogram and divide asymmetrically to produce neuronal precursor cells that differentiate into the lost neurons. However, little is understood about the early signals that induce this response. Ciliary neurotrophic factor (CNTF) was previously shown to be both neuroprotective and pro-proliferative within the zebrafish retina, however CNTF is not expressed following injury. Here we demonstrate that alternative ligands of the Ciliary neurotrophic factor receptor (CNTFR), such as Cardiotrophin-like cytokine factor 1 (Clcf1) and Cytokine receptor-like factor 1a (Crlf1a), are expressed within Müller glia of the light-damaged retina. We found that C

SUBMITTER:  

PROVIDER: S-EPMC9950120 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature