Comprehensive transcriptomic profiling and mutational landscape of primary gastric linitis plastica.

ABSTRACT:

Background

Primary gastric linitis plastica (GLP) is a distinct phenotype of gastric cancer with poor survival. Comprehensive molecular profiles and putative therapeutic targets of GLP remain undetermined.

Methods

We subjected 10 tumor-normal tissue pairs to whole exome sequencing (WES) and whole transcriptome sequencing (WTS). 10 tumor samples were all GLP which involves 100% of the gastric wall macroscopically. TCGA data were compared to generate the top mutated genes and the overexpressed genes in GLP.

Results

Our results reveal that GLP has distinctive genomic and transcriptomic features, dysfunction in the Hippo pathway is likely to be a key step during GLP development. 6 genes were identified as significantly highly mutated genes in GLP, including AOX1, ANKRD36C

SUBMITTER: Liu Z 

PROVIDER: S-EPMC9950178 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature