Global longitudinal strain: an early marker for cardiotoxicity in patients treated for breast cancer.

ABSTRACT:

Background

Patients treated with anthracyclines and trastuzumab are at increased risk of developing heart failure. Early diagnosis and treatment may prevent irreversible left ventricular (LV) dysfunction. This study investigates whether subclinical deterioration of global longitudinal strain (GLS) is a more reliable early predictor for LV dysfunction than three-dimensional (3D) LV ejection fraction (LVEF).

Methods

Adult patients receiving anthracyclines and trastuzumab for breast cancer who had serial echocardiographic follow-up were included in this retrospective study. The primary endpoint was the necessity to temporarily pause chemo- or immunotherapy due to declining LVEF (decline in 3D LVEF of > 10 percentage points to < 53%). Linear mixed-effects models were used to ass

SUBMITTER: van der Linde D 

PROVIDER: S-EPMC9950304 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature