High dose isoleucine stabilizes nuclear PTEN to suppress the proliferation of lung cancer.

ABSTRACT:

Purpose

Cancer cells require a supply of amino acids, particularly essential amino acids such as branched-chain amino acids (BCAAs, i.e., valine, leucine, and isoleucine), to meet the increased nutrient demands of malignant tumors. The cell-autonomous and non-autonomous roles of altered BCAA supply have been implicated in cancer progression. The critical proteins involved in BCAA uptake, transport, metabolism, etc. serve as potential therapeutic biomarkers in human cancers. Here, we summarize the potential anti-tumor mechanism of BCAA by exploring the chain reaction triggered by increased BCAA supply in the tumor.

Method

A system-wide strategy was employed to provide a generic solution to establish the links between BCAA and cancer based on comprehensive omics, molecular exp

SUBMITTER: Wang H 

PROVIDER: S-EPMC9950318 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature