Diagnostic value of metagenomic next-generation sequencing in sepsis and bloodstream infection

ABSTRACT:

Objective

To evaluate the diagnostic value of metagenomic next-generation sequencing (mNGS) in sepsis and bloodstream infection (BSI).

Methods

A retrospective analysis of patients diagnosed with sepsis and BSI at the First Affiliated Hospital of Zhengzhou University from January 2020 to February 2022 was conducted. All the patients underwent blood culture and were divided into mNGS group and non-mNGS group according to whether mNGS was performed or not. The mNGS group was further divided into early group (< 1 day), intermediate group (1–3 days), and late group (> 3 days) according to the time of mNGS inspection.

Results

In 194 patients with sepsis and BSI, the positive rate of mNGS for identifying pathogens was significantly higher than that of blood culture (77.

SUBMITTER: Qin C 

PROVIDER: S-EPMC9950395 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature