Adeno-associated virus receptor complexes and implications for adeno-associated virus immune neutralization.

ABSTRACT: Adeno-associated viruses (AAV) are among the foremost vectors for in vivo gene therapy. A number of monoclonal antibodies against several serotypes of AAV have previously been prepared. Many are neutralizing, and the predominant mechanisms have been reported as the inhibition of binding to extracellular glycan receptors or interference with some post-entry step. The identification of a protein receptor and recent structural characterization of its interactions with AAV compel reconsideration of this tenet. AAVs can be divided into two families based on which domain of the receptor is strongly bound. Neighboring domains, unseen in the high-resolution electron microscopy structures have now been located by electron tomography, pointing away from the virus. The epitopes of neutralizing

SUBMITTER: Large EE 

PROVIDER: S-EPMC9950413 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature