Advances on the early cellular events occurring upon exposure of human macrophages to aluminum oxyhydroxide adjuvant.

ABSTRACT: Aluminum compounds are the most widely used adjuvants in veterinary and human vaccines. Despite almost a century of use and substantial advances made in recent decades about their fate and biological effects, the exact mechanism of their action has been continuously debated, from the initial "depot-theory" to the direct immune system stimulation, and remains elusive. Here we investigated the early in vitro response of primary human PBMCs obtained from healthy individuals to aluminum oxyhydroxide (the most commonly used adjuvant) and a whole vaccine, in terms of internalization, conventional and non-conventional autophagy pathways, inflammation, ROS production, and mitochondrial metabolism. During the first four hours of contact, aluminum oxyhydroxide particles, with or without adsorbed vac

SUBMITTER: Masson JD 

PROVIDER: S-EPMC9950428 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature