Micro-mechanical fingerprints of the rat bladder change in actinic cystitis and tumor presence.

ABSTRACT: Tissue mechanics determines tissue homeostasis, disease development and progression. Bladder strongly relies on its mechanical properties to perform its physiological function, but these are poorly unveiled under normal and pathological conditions. Here we characterize the mechanical fingerprints at the micro-scale level of the three tissue layers which compose the healthy bladder wall, and identify modifications associated with the onset and progression of pathological conditions (i.e., actinic cystitis and bladder cancer). We use two indentation-based instruments (an Atomic Force Microscope and a nanoindenter) and compare the micromechanical maps with a comprehensive histological analysis. We find that the healthy bladder wall is a mechanically inhomogeneous tissue, with a gradient of in

SUBMITTER: Martinez-Vidal L 

PROVIDER: S-EPMC9950451 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature