[¹⁸F]Tosyl fluoride as a versatile [¹⁸F]fluoride source for the preparation of ¹⁸F-labeled radiopharmaceuticals.

ABSTRACT: Positron emission tomography (PET) is an in vivo imaging technology that utilizes positron-emitting radioisotope-labeled compounds as PET radiotracers that are commonly used in clinic and in various research areas, including oncology, cardiology, and neurology. Fluorine-18 is the most widely used PET-radionuclide and commonly produced by proton bombardment of ¹⁸O-enriched water in a cyclotron. The [¹⁸F]fluoride thus obtained generally requires processing by azeotropic drying in order to completely remove H₂O before it can be used for nucleophilic radiofluorination. In general, the drying step is important in facilitating the radiofluorination reactions and the preparation of ¹⁸F-labeled PET radiotracers. In this communication, we have demonstrate

SUBMITTER: Zhou D 

PROVIDER: S-EPMC9950486 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature