Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age.

ABSTRACT: Conditions such as small for gestational age (SGA), which is defined as birthweight less than 10^th percentile for gestational age can predispose to neurodevelopmental abnormalities compared to babies with normal birthweight. Fetal growth and birthweight depend on placental function, as this organ transports substrates to the developing fetus and it acts as a source of endocrine factors, including steroids and prolactins that are required for fetal development and pregnancy maintenance. To advance our knowledge on the aetiology of fetal growth disorders, the vast majority of the research has been focused on studying the transport function of the placenta, leaving practically unexplored the contribution of placental hormones in the regulation of fetal growth. Here, using mice and

SUBMITTER: Lopez-Tello J 

PROVIDER: S-EPMC9950515 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature