Disturbed functional connectivity and topological properties of the frontal lobe in minimally conscious state based on resting-state fNIRS.

ABSTRACT:

Background

Patients in minimally conscious state (MCS) exist measurable evidence of consciousness. The frontal lobe is a crucial part of the brain that encodes abstract information and is closely related to the conscious state. We hypothesized that the disturbance of the frontal functional network exists in MCS patients.

Methods

We collected the resting-state functional near-infrared spectroscopy (fNIRS) data of fifteen MCS patients and sixteen age- and gender-matched healthy controls (HC). The Coma Recovery Scale-Revised (CRS-R) scale of MCS patients was also composed. The topology of the frontal functional network was analyzed in two groups.

Results

Compared with HC, the MCS patients showed widely disrupted functional connectivity in the frontal lobe, especially in

SUBMITTER: Chen H 

PROVIDER: S-EPMC9950516 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature