Sex and diet-dependent gene alterations in human and rat brains with a history of nicotine exposure.

ABSTRACT:

Introduction

Chronic nicotine exposure induces changes in the expression of key regulatory genes associated with metabolic function and neuronal alterations in the brain. Many bioregulatory genes have been associated with exposure to nicotine, but the modulating effects of sex and diet on gene expression in nicotine-exposed brains have been largely unexplored. Both humans and rodents display motivation for nicotine use and the emergence of withdrawal symptoms during abstinence. Research comparing pre-clinical models with human subjects provides an important opportunity to understand common biomarkers of the harmful effects of nicotine as well as information that may help guide the development of more effective interventions for nicotine cessation.

Methods

Human postmortem do

SUBMITTER: Vargas-Medrano J 

PROVIDER: S-EPMC9950561 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature