Association of GBA genotype with motor and cognitive decline in Chinese Parkinson's disease patients.

ABSTRACT:

Objective

Variants in the glucocerebrosidase (GBA) gene are the most common and significant risk factor for Parkinson's disease (PD). However, the impact of GBA variants on PD disease progression in the Chinese population remains unclear. This study aimed to explore the significance of GBA status on motor and cognitive impairment in a longitudinal cohort of Chinese patients with PD.

Methods

The entire GBA gene was screened by long-range polymerase chain reaction (LR-PCR) and next generation sequencing (NGS). A total of 43 GBA-related PD (GBA-PD) and 246 non-GBA-mutated PD (NM-PD) patients with complete clinical data at baseline and at least one follow-up were recruited for this study. The associations of GBA genotype wi

SUBMITTER: Ren J 

PROVIDER: S-EPMC9950580 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature