Systemic inflammatory regulators and proliferative diabetic retinopathy: A bidirectional Mendelian randomization study.

ABSTRACT:

Background

Increasing evidence shows that systemic inflammation is an embedded mechanism of proliferative diabetic retinopathy (PDR). However, the specific systemic inflammatory factors involved in this process remained obscure. The study aimed to identify the upstream and downstream systemic regulators of PDR by using Mendelian randomization (MR) analyses.

Methods

We performed a bidirectional two-sample MR analysis implementing the results from genome-wide association studies for 41 serum cytokines from 8,293 Finnish individuals, and PDR from FinnGen consortium (2,025 cases vs. 284,826 controls) and eight cohorts of European ancestry (398 cases vs. 2,848 controls), respectively. The inverse-variance-weighted method was adopted as the main MR method, and four additional MR m

SUBMITTER: Shi Q 

PROVIDER: S-EPMC9950638 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature