Population-based genomic study of <i>Plasmodium vivax</i> malaria in seven Brazilian states and across South America.

ABSTRACT:

Background

Brazil is a unique and understudied setting for malaria, with complex foci of transmission associated with human and environmental conditions. An understanding of the population genomic diversity of P. vivax parasites across Brazil can support malaria control strategies.

Methods

Through whole genome sequencing of P. vivax isolates across 7 Brazilian states, we use population genomic approaches to compare genetic diversity within country (n = 123), continent (6 countries, n = 315) and globally (26 countries, n = 885).

Findings

We confirm that South American isolates are distinct, have more ancestral populations than the other global regions, with differentiating mutations in genes under selective pressure linked to antimalarial drugs (pvmdr1

SUBMITTER: Ibrahim A 

PROVIDER: S-EPMC9950661 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature