Prognostic value of growth differentiation factor-15 in patients with coronary artery disease: A meta-analysis and systematic review.

ABSTRACT:

Background and aims

The predictive value of growth differentiation factor-15 (GDF-15) for individual cardiovascular outcomes remained controversial in patients with coronary artery disease (CAD). We aimed to investigate the effects of GDF-15 on all-cause death, cardiovascular death, MI and stroke in CAD patients.

Methods

We searched PubMed, EMBASE, Cochrane library and Web of Science till 30 December, 2020. Hazard ratios (HRs) were combined with fixed or random effect meta-analyses. Subgroup analyses were performed in different disease types. Sensitivity analyses were used to evaluate the stability of the results. Publication bias was tested using funnel plots.

Results

A total of 10 studies with 49,443 patients were included in this meta-analysis. Patients with the hi

SUBMITTER: Zhang S 

PROVIDER: S-EPMC9950748 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature