Rest phase snacking increases energy resorption and weight gain in male mice.

ABSTRACT:

Objective

Snacking, i.e., the intake of small amounts of palatable food items, is a common behavior in modern societies, promoting overeating and obesity. Shifting food intake into the daily rest phase disrupts circadian rhythms and is also known to stimulate weight gain. We therefore hypothesized that chronic snacking in the inactive phase may promote body weight gain and that this effect is based on disruption of circadian clocks.

Methods

Male mice were fed a daily chocolate snack either during their rest or their active phase and body weight development and metabolic parameters were investigated. Snacking experiments were repeated in constant darkness and in clock-deficient mutant mice to examine the role of external and internal time cues in mediating the metabolic effec

SUBMITTER: Begemann K 

PROVIDER: S-EPMC9950950 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature