Median eminence myelin continuously turns over in adult mice.

ABSTRACT:

Objective

Oligodendrocyte progenitor cell differentiation is regulated by nutritional signals in the adult median eminence (ME), but the consequences on local myelination are unknown. The aim of this study was to characterize myelin plasticity in the ME of adult mice in health or in response to chronic nutritional challenge and determine its relevance to the regulation of energy balance.

Methods

We assessed new oligodendrocyte (OL) and myelin generation and stability in the ME of healthy adult male mice using bromodeoxyuridine labelling and genetic fate mapping tools. We evaluated the contribution of microglia to ME myelin plasticity in PLX5622-treated C57BL/6J mice and in Pdgfra-Cre/ER^T2;R26R-eYFP;Myrf^fl/fl mice, where adult oligodendrogenesis is blunt

SUBMITTER: Buller S 

PROVIDER: S-EPMC9950957 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature