Treg-selective IL-2 starvation synergizes with CD40 activation to sustain durable responses in lymphoma models.

ABSTRACT:

Background

Roughly half of all diffuse large B-cell lymphomas (DLBCLs) are infiltrated by large numbers of regulatory T-cells (Tregs). Although the presence of 'effector' Tregs in particular is associated with an inferior prognosis in patients on standard rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) immunochemotherapy, the role of this cell type during lymphoma initiation and progression is poorly understood.

Methods

Here, we use tissue microarrays containing prospectively collected DLBCL patient specimens, as well as data from publicly available cohorts to explore the mutational landscape of Treg-infiltrated DLBCL. We further take advantage of a model of MYC-driven lymphoma to mechanistically dissect the contribution of Tregs to lymphom

SUBMITTER: Stirm K 

PROVIDER: S-EPMC9950978 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature