Association of Proton Pump Inhibitor Use With Risk of Acquiring Drug-Resistant Enterobacterales.

ABSTRACT:

Importance

Proton-pump inhibitors (PPIs) have been associated with the risk of colonization with drug-resistant bacteria; however, possible confounding by lifestyle-associated factors and disease severity casts doubt on this association, and whether the risk is dose dependent is not known.

Objectives

To assess the association between PPI use and the risk of acquiring drug-resistant Enterobacterales and to examine interactions with possible microbiome-altering agents.

Design, setting, and participants

This nested case-control study involved 2239 hospitalized adult (aged ≥18 years) patients identified from the microbiology laboratory database of Amsterdam University Medical Centers between December 31, 2018, and January 6, 2021. Patients in the case group had newly dete

SUBMITTER: Willems RPJ 

PROVIDER: S-EPMC9951039 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature