Physical Frailty and Brain White Matter Abnormalities: The Atherosclerosis Risk in Communities Study.

ABSTRACT:

Background

Physical frailty is associated with increased risk for dementia and other neurologic sequelae. However, the neurobiological changes underlying frailty and frailty risk remain unknown. We examined the association of cerebral white matter structure with current and future frailty.

Methods

Atherosclerosis Risk in Communities Study Neurocognitive Study participants who underwent 3T brain MRI were included. Frailty status was classified according to the Fried criteria. Cerebral white matter integrity was defined using white matter hyperintensity (WMH) volume and microstructure, measured using diffusion tensor imaging fractional anisotropy (FA) and mean diffusivity (MD). Multivariable linear regression was used to relate baseline frailty to white matter structure; multi

SUBMITTER: Ducca EL 

PROVIDER: S-EPMC9951053 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature