Genetic and Environmental Influences on Longitudinal Frailty Trajectories From Adulthood into Old Age.

ABSTRACT:

Background

Frailty is a complex, dynamic geriatric condition, but limited evidence has shown how genes and environment may contribute to its longitudinal changes. We sought to investigate sources of individual differences in the longitudinal trajectories of frailty, considering potential selection bias when including a sample of oldest-old twins.

Methods

Data were from 2 Swedish twin cohort studies: a younger cohort comprising 1 842 adults aged 29-96 years followed up to 15 waves, and an older cohort comprising 654 adults aged ≥79 years followed up to 5 waves. Frailty was measured using the frailty index (FI). Age-based latent growth curve models were used to examine longitudinal trajectories, and extended to a biometric analysis to decompose variability into genetic and env

SUBMITTER: Mak JKL 

PROVIDER: S-EPMC9951061 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature