Brain Changes and Fast Cognitive and Motor Decline in Older Adults.

ABSTRACT:

Background

To identify brain magnetic resonance imaging (MRI) signatures characterizing people with different patterns of decline in cognition and motor function.

Methods

In the Swedish National Study on Aging and Care in Kungsholmen, Stockholm, 385 participants had available repeated brain MRI examinations, where markers of brain volumes and white matter integrity were assessed. The speed of cognitive and motor decline was estimated as the rate of a Mini-Mental State Examination and gait speed decline over 12 years (linear mixed models), and further dichotomized into the upper (25% fastest rate of decline) versus the lower quartiles. Participants were grouped in slow/no decliners (reference), isolated motor decliners, isolated cognitive decliners, and cognitive and motor de

SUBMITTER: Grande G 

PROVIDER: S-EPMC9951062 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature