Association of Surgical Margin Distance With Survival in Patients With Resected Head and Neck Squamous Cell Carcinoma: A Secondary Analysis of a Randomized Clinical Trial.

ABSTRACT:

Importance

Clear surgical margins reduce the risk of local recurrence, improve survival, and determine decision-making with regard to adjuvant treatment of squamous cell carcinoma of the head and neck (SCCHN). However, the definitions of clear, close, or positive surgical margins vary in both the literature and in practice.

Objective

To examine whether the association between surgical margin distance and survival varies by primary tumor site.

Design, setting, and participants

This was a secondary analysis of a multi-institutional, multinational randomized clinical trial. The trial enrolled patients from January 22, 2007, to March 29, 2013, with stage II to IVA resected SCCHN with extranodal extension (ENE) or positive margins (<5 mm from invasive tumor to the resected

SUBMITTER: Sunkara PR 

PROVIDER: S-EPMC9951098 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature