Nanopore Discrimination of Coagulation Biomarker Derivatives and Characterization of a Post-Translational Modification.

ABSTRACT: One of the most important health challenges is the early and ongoing detection of disease for prevention, as well as personalized treatment management. Development of new sensitive analytical point-of-care tests are, therefore, necessary for direct biomarker detection from biofluids as critical tools to address the healthcare needs of an aging global population. Coagulation disorders associated with stroke, heart attack, or cancer are defined by an increased level of the fibrinopeptide A (FPA) biomarker, among others. This biomarker exists in more than one form: it can be post-translationally modified with a phosphate and also cleaved to form shorter peptides. Current assays are long and have difficulties in discriminating between these derivatives; hence, this is an underutilized biomarke

SUBMITTER: Stierlen A 

PROVIDER: S-EPMC9951287 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature