Metabolic profiling of pregnancies complicated by preeclampsia: A longitudinal study.

ABSTRACT:

Introduction

Preeclampsia is associated with maternal metabolic disturbances, but longitudinal studies with comprehensive metabolic profiling are lacking. We aimed to determine metabolic profiles across gestation in women who developed preeclampsia compared with women with healthy pregnancies. We also explored the respective effects of body mass index (BMI) and preeclampsia on various metabolic measures.

Material and methods

We measured 91 metabolites by high-throughput nuclear magnetic resonance spectroscopy at four time points (visits) during pregnancy (weeks 14-16, 22-24, 30-32 and 36-38). Samples were taken from a Norwegian pregnancy cohort. We fitted a linear regression model for each metabolic measure to compare women who developed preeclampsia (n = 38) and healthy con

SUBMITTER: Skytte HN 

PROVIDER: S-EPMC9951333 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature